Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease ...
Deep inside every mammalian cell, a molecular machine works around the clock to shred damaged, misfolded, and obsolete ...
Cells organize their molecules into distinct functional areas. While textbooks usually refer to membrane-bound organelles such as mitochondria and cell nuclei, recent studies have also revealed ...
The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but ...
Managing the waste that cells produce is an essential function of the human body, as any defect in its elimination mechanisms can lead to cancer and neurodegenerative diseases. Now a Canadian study ...
Many therapeutic targets escape druggability by mysterious molecular motions that cannot be precisely visualized. This ‘dark-world’ reality is particularly augmented in the ubiquitin-proteasome system ...
Recent research from the lab of Dr. Nicolas Lehrbach, an Assistant Professor in the Basic Sciences Division at Fred Hutch, discovered that altering nucleotide metabolism may bypass proteasome defects ...
Researchers from the Universitat Jaume I of Castelló (Spain) and the Max Planck Institute (Germany) have developed new proteasome inhibitors with different pharmacological properties to those ...
The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but ...
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